Crit Care. 2004 Aug;8(4):R248-50. Epub 2004 Jun 15.

Marked elevations in N-terminal brain natriuretic peptide levels in septic shock.

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Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, Singapore. geraldswchua@yahoo.com.sg <geraldswchua@yahoo.com.sg>

Abstract

INTRODUCTION:

N-terminal pro brain natriuretic peptide (NT-proBNP) is a cardiac biomarker that has recently shown to be of diagnostic value in a diagnosis of decompensated heart failure, acute coronary syndromes and other conditions resulting in myocardial stretch. We sought to study whether sepsis-induced myocardial dilation would result in an elevation of NT-proBNP.

METHOD:

Serum NT-proBNP measurements were made in six consecutive patients with septic shock within 6 hours of admission to the intensive care unit.

RESULTS:

Markedly elevated levels of NT-proBNP were found in all six patients.

CONCLUSIONS:

NT-proBNP levels can be markedly elevated in critically ill patients presenting with septic shock. An elevated NT-proBNP level in a critically ill patient is not specific for decompensated heart failure.

PMID:: 15312225; [PubMed - indexed for MEDLINE]
PMCID: PMC522851

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Chemical compound information

Natriuretic Peptide, Brain

MW: 3466.05 g/mol

MF: C₁₄₃H₂₄₆N₅₀O₄₂S₄

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Marked elevations in N-terminal brain natriuretic peptide levels in septic shock.

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