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    Science. 1992 Sep 4;257(5075):1398-400.

    MacroH2A, a core histone containing a large nonhistone region.

    Pehrson JR, Fried VA.

    Source

    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111.

    Abstract

    A histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes. Its N-terminal third is 64 percent identical to a full-length mouse H2A. However, it also contains a large nonhistone region. This region has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors. Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins.

    PMID:
    1529340
    [PubMed - indexed for MEDLINE]

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