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Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10602-7. Epub 2004 Jul 12.

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

Dechow TN, Pedranzini L, Leitch A, Leslie K, Gerald WL, Linkov I, Bromberg JF.

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Laboratory of Molecular Cell Biology, The Rockefeller University, New York, NY 10021, USA.

Abstract

Persistently activated Stat3 is found in many different cancers, including approximately 60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis.

PMID:: 15249664; [PubMed - indexed for MEDLINE]
PMCID:: PMC489981

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