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    Res Commun Mol Pathol Pharmacol. 2002;111(5-6):245-51.

    Surfactant protein A and D (SP-A, AP-D) levels in patients with septic ARDS.

    Endo S, Sato N, Nakae H, Yamada Y, Makabe H, Abe H, Imai S, Wakabayashi G, Inada K, Sato S.

    Source

    Department of Critical Care Medicine, Iwate Medical University, 19-1 Uchimaru, Morioaka 0202-8505, Japan. sendo@iwate-med.ac.jp

    Abstract

    The levels of surfactant protein-A (SP-A) and surfactant protein-D (SP-D) in the serum of patients with septic acute respiratory distress syndrome (ARDS) were determined. Patients with sepsis without ARDS were examined as controls. The mean serum SP-A level in the former group was 37.6 +/- 16.2 ng/ml and in the latter group was 31.8 +/- 9.6 ng/ml. The difference between the two groups was not statistically significant. The maximum serum SP-D level was 83.0 +/- 33.9 ng/ml in the control group of patients without ARDS, and 476.3 +/- 391.2 ng/ml in the patients with ARDS. The level in the latter population was significantly higher than that in the former population. No significant correlation was observed between the SP-A and SP-D levels. These results suggest that the serum SP-D levels may serve as a good diagnostic indicator of ARDS in patients with sepsis.

    PMID:
    15244040
    [PubMed - indexed for MEDLINE]

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