AIDS. 2004 Jul 23;18(11):1598-600.

A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.

Braida L, Boniotto M, Pontillo A, Tovo PA, Amoroso A, Crovella S.

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Dipartimento di Scienze delle Riproduzione e dello Sviluppo, University of Trieste, Italy.

Abstract

In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.

Comment in

AIDS. 2009 Mar 13;23(5):647-9; author reply 649-50.

PMID:: 15238780; [PubMed - indexed for MEDLINE]

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