Tex Heart Inst J. 1986 Mar;13(1):77-82.

Effect of surgery and cardiopulmonary bypass on indocyanine green pharmacokinetics.

Source

Department of Pharmaceutics, University of Houston, Texas Medical Center, Houston, Texas 77030, USA.

Abstract

The pharmacokinetics of indocyanine green (ICG), a marker for hepatic blood flow (HBF), were studied at selected times during the initial 24-hour postoperative period in patients undergoing cardiac surgery with (n = 33) and without (n = 13) cardiopulmonary bypass. Cardiopulmonary bypass (CPB) caused a depression in ICG clearance and, by implication, HBF, reaching 48% of the pre-anesthetic and 60% of the pre-bypass values 2 hours post-CPB, returning to control values between 8 and 12 hours post-CPB. Similar decreases, although to a lesser extent, were seen in the non-CPB patients. Simulations with model compounds showed that these changes could produce clinically significant alterations in drug concentration-time profiles.

PMID:: 15226835; [PubMed]
PMCID:: PMC324601

Free PMC Article

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Splanchnic oxygen transport, hepatic function and gastrointestinal barrier after normothermic cardiopulmonary bypass. [Acta Anaesthesiol Scand. 2004]
Splanchnic oxygen transport, hepatic function and gastrointestinal barrier after normothermic cardiopulmonary bypass.
Braun JP, Schroeder T, Buehner S, Dohmen P, Moshirzadeh M, Grosse J, Streit F, Schlaefke A, Armstrong VW, Oellerich M, et al. Acta Anaesthesiol Scand. 2004 Jul; 48(6):697-703.
Indocyanine green clearance after cardiac surgery: the impact of cardiopulmonary bypass. [Perfusion. 2012]
Indocyanine green clearance after cardiac surgery: the impact of cardiopulmonary bypass.
Möhnle P, Kilger E, Adnan L, Beiras-Fernandez A, Vicol C, Weis F. Perfusion. 2012 Feb 21; . Epub 2012 Feb 21.
The effect of fenoldopam and dopexamine on hepatic blood flow and hepatic function following coronary artery bypass grafting with hypothermic cardiopulmonary bypass. [Eur J Cardiothorac Surg. 2009]
The effect of fenoldopam and dopexamine on hepatic blood flow and hepatic function following coronary artery bypass grafting with hypothermic cardiopulmonary bypass.
Adluri RK, Singh AV, Skoyles J, Robins A, Hitch A, Baker M, Mitchell IM. Eur J Cardiothorac Surg. 2009 Jun; 35(6):988-94. Epub 2009 Apr 29.
Assessment of metabolic liver function and hepatic blood flow during cardiopulmonary bypass. [Thorac Cardiovasc Surg. 1996]
Assessment of metabolic liver function and hepatic blood flow during cardiopulmonary bypass.
Autschbach R, Falk V, Lange H, Oellerich M, Walther T, Mohr FW, Dalichau H. Thorac Cardiovasc Surg. 1996 Apr; 44(2):76-80.
Does a hyperoncotic cardiopulmonary bypass prime affect extravascular lung water and cardiopulmonary function in patients undergoing coronary artery bypass surgery? [Eur J Cardiothorac Surg. 2001]
Does a hyperoncotic cardiopulmonary bypass prime affect extravascular lung water and cardiopulmonary function in patients undergoing coronary artery bypass surgery?
Eising GP, Niemeyer M, Günther T, Tassani P, Pfauder M, Schad H, Lange R. Eur J Cardiothorac Surg. 2001 Aug; 20(2):282-9.

See reviews... See all...

Cited by 1 PubMed Central article

Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting--an observational study. [Crit Care. 2009]
Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting--an observational study.
Sander M, Spies CD, Berger K, Schröder T, Grubitzsch H, Wernecke KD, von Heymann C. Crit Care. 2009; 13(5):R149. Epub 2009 Sep 14.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effect of surgery and cardiopulmonary bypass on indocyanine green pharmacokineti...
Effect of surgery and cardiopulmonary bypass on indocyanine green pharmacokinetics.
Tex Heart Inst J. 1986 Mar ;13(1):77-82.

PubMed
Markers of risk of asthma death or readmission in the 12 months following a hosp...
Markers of risk of asthma death or readmission in the 12 months following a hospital admission for asthma.
Int J Epidemiol. 1992 Aug ;21(4):737-44.

PubMed
Prophylactic and therapeutic recombinant factor VIIa administration to patients ...
Prophylactic and therapeutic recombinant factor VIIa administration to patients with Glanzmann's thrombasthenia: results of an international survey.
J Thromb Haemost. 2004 Jul ;2(7):1096-103.

PubMed
Recollection of intensive care unit admission in the United Kingdom.
Recollection of intensive care unit admission in the United Kingdom.
Crit Care Med. 1992 Sep ;20(9):1363.

PubMed
Lessons learned from one hundred right lobe living donor liver transplants.
Lessons learned from one hundred right lobe living donor liver transplants.
Ann Surg. 2004 Jul ;240(1):151-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Effect of surgery and cardiopulmonary bypass on indocyanine green pharmacokinetics.

Source

Abstract

LinkOut - more resources

Full Text Sources

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information