Can J Microbiol. 1992 Feb;38(2):85-91.

O-acetylated peptidoglycan: its occurrence, pathobiological significance, and biosynthesis.

Source

Department of Microbiology, University of Guelph, Ont., Canada.

Abstract

Bacterial cell walls and their structural units, particularly peptidoglycan, induce a vast variety of biological effects in host organisms. The pathobiological effects of peptidoglycan are greatly enhanced by various modifications and substitutions to its basic composition and structure. One such modification is the presence of acetyl moieties at the C-6 hydroxyl group of N-acetylmuramyl residues, and to date, 11 species of eubacteria, including some important human pathogens, such as Neisseria gonorrhoeae, Proteus mirabilis, and Staphylococcus aureus, are known to possess O-acetylated peptidoglycan. This review addresses the influence of O-acetylation of peptidoglycan on its resistance to degradation both in vitro and in vivo, the clinical importance of the modification, and the currently held views on the pathway for its biosynthesis.

PMID:: 1521192; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Identification and characterization of O-acetylpeptidoglycan esterase: a novel enzyme discovered in Neisseria gonorrhoeae. [Biochemistry. 2006]
Identification and characterization of O-acetylpeptidoglycan esterase: a novel enzyme discovered in Neisseria gonorrhoeae.
Weadge JT, Clarke AJ. Biochemistry. 2006 Jan 24; 45(3):839-51.
Identification of a new family of enzymes with potential O-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria. [BMC Microbiol. 2005]
Identification of a new family of enzymes with potential O-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria.
Weadge JT, Pfeffer JM, Clarke AJ. BMC Microbiol. 2005 Aug 19; 5:49. Epub 2005 Aug 19.
Evidence for N----O acetyl migration as the mechanism for O acetylation of peptidoglycan in Proteus mirabilis. [J Bacteriol. 1991]
Evidence for N----O acetyl migration as the mechanism for O acetylation of peptidoglycan in Proteus mirabilis.
Dupont C, Clarke AJ. J Bacteriol. 1991 Jul; 173(14):4318-24.
Review Structural variation in the glycan strands of bacterial peptidoglycan. [FEMS Microbiol Rev. 2008]
Review Structural variation in the glycan strands of bacterial peptidoglycan.
Vollmer W. FEMS Microbiol Rev. 2008 Mar; 32(2):287-306. Epub 2007 Dec 5.
Review Assembly of the monomer unit of bacterial peptidoglycan. [Cell Mol Life Sci. 1998]
Review Assembly of the monomer unit of bacterial peptidoglycan.
van Heijenoort J. Cell Mol Life Sci. 1998 Apr; 54(4):300-4.

See reviews... See all...

Cited by 25 PubMed Central articles

Evaluation of methods for the extraction and purification of DNA from the human microbiome. [PLoS One. 2012]
Evaluation of methods for the extraction and purification of DNA from the human microbiome.
Yuan S, Cohen DB, Ravel J, Abdo Z, Forney LJ. PLoS One. 2012; 7(3):e33865. Epub 2012 Mar 23.
Peptidoglycan-modifying enzyme Pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni. [PLoS Pathog. 2012]
Peptidoglycan-modifying enzyme Pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni.
Frirdich E, Biboy J, Adams C, Lee J, Ellermeier J, Gielda LD, Dirita VJ, Girardin SE, Vollmer W, Gaynor EC. PLoS Pathog. 2012 Mar; 8(3):e1002602. Epub 2012 Mar 22.
A new role for an old antimicrobial: lysozyme c-1 can function to protect malaria parasites in Anopheles mosquitoes. [PLoS One. 2011]
A new role for an old antimicrobial: lysozyme c-1 can function to protect malaria parasites in Anopheles mosquitoes.
Kajla MK, Shi L, Li B, Luckhart S, Li J, Paskewitz SM. PLoS One. 2011 May 6; 6(5):e19649. Epub 2011 May 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

O-acetylated peptidoglycan: its occurrence, pathobiological significance, and bi...
O-acetylated peptidoglycan: its occurrence, pathobiological significance, and biosynthesis.
Can J Microbiol. 1992 Feb ;38(2):85-91.

PubMed
Linkage disequlibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p...
Linkage disequlibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: findings from identity by descent haplotype sharing analysis.
Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1 ;128B(1):65-70.

PubMed
The role of transthyretin in the transport of thyroid hormone to cerebrospinal f...
The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain.
Acta Med Austriaca. 1992 ;19 Suppl 1:25-8.

PubMed
Fibroblast growth factor-2 induces osteoblast survival through a phosphatidylino...
Fibroblast growth factor-2 induces osteoblast survival through a phosphatidylinositol 3-kinase-dependent, -beta-catenin-independent signaling pathway.
Exp Cell Res. 2004 Jul 1 ;297(1):235-46.

PubMed
Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mit...
Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.
J Mol Biol. 1992 Aug 20 ;226(4):1051-72.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: