Curr Opin Mol Ther. 2004 Apr;6(2):141-5.

RNA interference as an antiviral approach: targeting HIV-1.

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University of Amsterdam, Department of Human Retrovirology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. b.berkhout@amc.uva.nl

Abstract

RNA interference (RNAi) is an evolutionary conserved gene-silencing mechanism in which 21- to 23-mer double-stranded short interfering RNA (siRNA) mediates the sequence-specific degradation of mRNA. The recent discovery that exogenously delivered siRNA can trigger RNAi in mammalian cells raises the possibility of using this technology as a therapeutic tool against pathogenic viruses. This review describes the antiviral RNAi field, which is barely two years-old, with an emphasis on recent studies aimed at suppression of HIV-1.

PMID:: 15195925; [PubMed - indexed for MEDLINE]

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RNA, Small Interfering

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RNA interference as an antiviral approach: targeting HIV-1.

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