Malar J. 2004 Jun 8;3:14.

Malarone treatment failure not associated with previously described mutations in the cytochrome b gene.

Wichmann O, Muehlen M, Gruss H, Mockenhaupt FP, Suttorp N, Jelinek T.

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Institute of Tropical Medicine, Charité, Humboldt University, Berlin, Germany. ole.wichmann@charite.de

Abstract

Malarone (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are associated with mutations at codon 268 of the parasite's cytochrome b gene. We report the first case of Malarone treatment failure from Central Africa.Drug concentration was well within curative range. Pre- and post-treatment Plasmodium falciparum isolates revealed codon 268 wild-type alleles, and no other mutations of the putative atovaquone-binding domain.These findings illustrate the spread of atovaquone-proguanil-resistance in Africa and question the usefulness of codon 268 as the only target for the surveillance of its emergence.

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PMCID: PMC425592

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Cited by 5 PubMed Central articles

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Chemical compound information

Proguanil

MW: 253.73 g/mol

MF: C₁₁H₁₆ClN₅

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