Mini Rev Med Chem. 2004 Jun;4(5):523-43.

Antiviral activity of ribosome inactivating proteins in medicine.

Source

Biotechnology Center for Agriculture and the Environment and the Department of Plant Biology and Pathology, Cook College, Rutgers University, New Brunswick, NJ 08903, USA.

Abstract

Pokeweed antiviral protein and several other ribosome inactivating proteins are effective against a broad range of viruses. Recent results have shown that their enzymatic activity is not limited to depurination of the large rRNA, they can depurinate other nucleic acids, including viral RNAs. Antiviral activity of RIPs is summarized here in light of their novel activities and recent developments in the field.

PMID:: 15180509; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Libraries

LinkOut Holdings

Supplemental Content

Icon for Bentham Science Publishers Ltd.

Save items

Related citations in PubMed

Pokeweed antiviral protein regulates the stability of its own mRNA by a mechanism that requires depurination but can be separated from depurination of the alpha-sarcin/ricin loop of rRNA. [J Biol Chem. 2002]
Pokeweed antiviral protein regulates the stability of its own mRNA by a mechanism that requires depurination but can be separated from depurination of the alpha-sarcin/ricin loop of rRNA.
Parikh BA, Coetzer C, Tumer NE. J Biol Chem. 2002 Nov 1; 277(44):41428-37. Epub 2002 Aug 8.
Depurination of plant ribosomes by pokeweed antiviral protein. [FEBS Lett. 1990]
Depurination of plant ribosomes by pokeweed antiviral protein.
Taylor BE, Irvin JD. FEBS Lett. 1990 Oct 29; 273(1-2):144-6.
A novel mechanism for inhibition of translation by pokeweed antiviral protein: depurination of the capped RNA template. [RNA. 2000]
A novel mechanism for inhibition of translation by pokeweed antiviral protein: depurination of the capped RNA template.
Hudak KA, Wang P, Tumer NE. RNA. 2000 Mar; 6(3):369-80.
Review Ribosome inactivating proteins from plants inhibiting viruses. [Virol Sin. 2011]
Review Ribosome inactivating proteins from plants inhibiting viruses.
Kaur I, Gupta RC, Puri M. Virol Sin. 2011 Dec; 26(6):357-65. Epub 2011 Dec 10.
Review Virus resistance mediated by ribosome inactivating proteins. [Adv Virus Res. 2000]
Review Virus resistance mediated by ribosome inactivating proteins.
Wang P, Tumer NE. Adv Virus Res. 2000; 55:325-55.

See reviews... See all...

Cited by 10 PubMed Central articles

Toxin-based therapeutic approaches. [Toxins (Basel). 2010]
Toxin-based therapeutic approaches.
Shapira A, Benhar I. Toxins (Basel). 2010 Nov; 2(11):2519-83. Epub 2010 Oct 28.
Engineered toxins "zymoxins" are activated by the HCV NS3 protease by removal of an inhibitory protein domain. [PLoS One. 2011]
Engineered toxins "zymoxins" are activated by the HCV NS3 protease by removal of an inhibitory protein domain.
Shapira A, Gal-Tanamy M, Nahary L, Litvak-Greenfeld D, Zemel R, Tur-Kaspa R, Benhar I. PLoS One. 2011 Jan 14; 6(1):e15916. Epub 2011 Jan 14.
The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin. [Cell Microbiol. 2008]
The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin.
Gupta PK, Liu S, Batavia MP, Leppla SH. Cell Microbiol. 2008 Aug; 10(8):1687-94. Epub 2008 May 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Antiviral activity of ribosome inactivating proteins in medicine.
Antiviral activity of ribosome inactivating proteins in medicine.
Mini Rev Med Chem. 2004 Jun ;4(5):523-43.

PubMed
Helicobacter pylori infection in children: clinical, endoscopic, and histologic ...
Helicobacter pylori infection in children: clinical, endoscopic, and histologic correlations.
J Pediatr Gastroenterol Nutr. 1992 May ;14(4):420-5.

PubMed
No long-term psychological reaction to information about increased risk of coron...
No long-term psychological reaction to information about increased risk of coronary heart disease in general practice.
Eur J Cardiovasc Prev Rehabil. 2004 Jun ;11(3):239-43.

PubMed
Intracranial ependymoma in children: analysis of prognostic factors.
Intracranial ependymoma in children: analysis of prognostic factors.
J Neurooncol. 1992 Jul ;13(3):283-90.

PubMed
Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus...
Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus).
Mar Environ Res. 2004 Aug-Dec ;58(2-5):119-24.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: