J Nat Prod. 1992 May;55(5):696-8.

Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum.

Jayasuriya H, Koonchanok NM, Geahlen RL, McLaughlin JL, Chang CJ.

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Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, Indiana 47907.

Abstract

Bioassay-directed fractionation of a Chinese medicinal plant, Polygonum cuspidatum (Polygonaceae), has led to the discovery of an anthraquinone, emodin [1], as a strong inhibitor of a protein tyrosine kinase (p56lck) partially purified from bovine thymus. Comparison of the IC50 values of emodin for protein tyrosine kinase inhibitory activity with physcion [2] and emodin-O8-D-glucoside [3], also isolated from the same plant, reveal the importance of the hydroxyl groups at C-6 and C-8 for the observed activity.

PMID:: 1517743; [PubMed - indexed for MEDLINE]

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CA50743/CA/NCI NIH HHS/United States

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