Allergy. 2004 Jun;59(6):561-70.

Eosinophils and atopic dermatitis.

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Department of Dermatology, Inselspital, University of Bern, CH-3010 Bern, Switzerland.

Abstract

In spite of the progress regarding the description of immunological phenomena associated with atopic dermatitis (AD), the pathogenesis of this disease still remains unclear. The presence of eosinophils in the inflammatory infiltrate of AD has long been established. Eosinophil numbers as well as eosinophil granule protein levels in peripheral blood are elevated in most AD patients and appear to correlate with disease activity. Moreover, eosinophil granule proteins, which possess cytotoxic activity, are deposited in the skin lesions. These observations indicate a role of eosinophils in the pathogenesis of AD. Furthermore, AD is associated with increased production of T helper 2 cytokines including interleukin (IL)-5, which specifically acts on eosinophils, resulting in accelerated eosinophilopoiesis, chemotaxis, cell activation, and delayed apoptosis. Therefore, IL-5 is an interesting target for experimental therapy in this inflammatory disorder of the skin. Such studies might result in new insights into the pathogenetic role of eosinophils in AD.

PMID:: 15147438; [PubMed - indexed for MEDLINE]

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Cited by 8 PubMed Central articles

Activation of Eosinophils Interacting with Dermal Fibroblasts by Pruritogenic Cytokine IL-31 and Alarmin IL-33: Implications in Atopic Dermatitis. [PLoS One. 2012]
Activation of Eosinophils Interacting with Dermal Fibroblasts by Pruritogenic Cytokine IL-31 and Alarmin IL-33: Implications in Atopic Dermatitis.
Wong CK, Leung KM, Qiu HN, Chow JY, Choi AO, Lam CW. PLoS One. 2012; 7(1):e29815. Epub 2012 Jan 17.
Th2 Cytokines and Atopic Dermatitis. [J Clin Cell Immunol. 2011]
Th2 Cytokines and Atopic Dermatitis.
Brandt EB, Sivaprasad U. J Clin Cell Immunol. 2011 Aug 10; 2(3).
Atopic dermatitis-like skin lesions reduced by topical application and intraperitoneal injection of Hirsutenone in NC/Nga mice. [Clin Dev Immunol. 2010]
Atopic dermatitis-like skin lesions reduced by topical application and intraperitoneal injection of Hirsutenone in NC/Nga mice.
Jeong MS, Choi SE, Kim JY, Kim JS, Kim EJ, Park KH, Lee do I, Joo SS, Lee CS, Bang H, et al. Clin Dev Immunol. 2010; 2010:618517. Epub 2010 Dec 14.

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