Cell. 1992 Aug 21;70(4):539-51.

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter.

Liu Y, Peter D, Roghani A, Schuldiner S, Privé GG, Eisenberg D, Brecha N, Edwards RH.

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Department of Neurology, University of California, School of Medicine, Los Angeles 90024-1769.

Abstract

Classical neurotransmitters are transported into synaptic vesicles so that their release can be regulated by neural activity. In addition, the vesicular transport of biogenic amines modulates susceptibility to N-methyl-4-phenylpyridinium (MPP+), the active metabolite of the neurotoxin N-methyl-1,2,3,6-tetrahydropyridine that produces a model of Parkinson's disease. Taking advantage of selection in MPP+, we have used gene transfer followed by plasmid rescue to identify a cDNA clone that encodes a vesicular amine transporter. The sequence predicts a novel mammalian protein with 12 transmembrane domains and homology to a class of bacterial drug resistance transporters. We have detected messenger RNA transcripts for this transporter only in the adrenal gland. Monoamine cell populations in the brain stem express a distinct but highly related protein.

PMID:: 1505023; [PubMed - indexed for MEDLINE]

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The molecular cloning and expression of a human synaptic vesicle amine transporter that suppresses MPP+ toxicity. [Brain Res Mol Brain Res. 1994]
The molecular cloning and expression of a human synaptic vesicle amine transporter that suppresses MPP+ toxicity.
Liu L, Xu W, Harrington KA, Emson PC. Brain Res Mol Brain Res. 1994 Aug; 25(1-2):90-6.
Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. [J Neurosci. 1993]
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Pifl C, Giros B, Caron MG. J Neurosci. 1993 Oct; 13(10):4246-53.
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Homology of a vesicular amine transporter to a gene conferring resistance to 1-methyl-4-phenylpyridinium.
Stern-Bach Y, Keen JN, Bejerano M, Steiner-Mordoch S, Wallach M, Findlay JB, Schuldiner S. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9730-3.
Review The transport of neurotransmitters into synaptic vesicles. [Prog Brain Res. 1995]
Review The transport of neurotransmitters into synaptic vesicles.
Peter D, Liu Y, Brecha N, Edwards RH. Prog Brain Res. 1995; 105:273-81.
Review The role of vesicular transport proteins in synaptic transmission and neural degeneration. [Annu Rev Neurosci. 1997]
Review The role of vesicular transport proteins in synaptic transmission and neural degeneration.
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