Neuron. 2004 Mar 25;41(6):845-8.

Retrograde regulation in the CNS; neuron-specific interpretations of TGF-beta signaling.

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Department of Molecular and Cellular Biology and ARL Division of Neurobiology, Box 210106, University of Arizona, Tucson, AZ 85721, USA.

Abstract

Retrograde signals influence neuronal survival, differentiation, synaptogenesis, and plasticity. Several recent papers describe novel roles for the well-studied TGF-beta pathway in retrograde synaptic signaling. While each dissects spatial and molecular aspects of TGF-beta signaling in a specific synaptic context, together these studies demonstrate that a specific retrograde signal may be interpreted in diverse, neuron-specific ways. Thus, a neuron's intrinsic properties and its other extrinsic signaling inputs determine its cellular and genomic response to TGF-beta.

PMID:: 15046717; [PubMed - indexed for MEDLINE]

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Transforming Growth Factor beta

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