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    Nat Neurosci. 2004 Apr;7(4):335-6. Epub 2004 Mar 14.

    Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.

    Fan W, Ellacott KL, Halatchev IG, Takahashi K, Yu P, Cone RD.

    Source

    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA. fanw@ohsu.edu

    Abstract

    Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

    PMID:
    15034587
    [PubMed - indexed for MEDLINE]

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