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    Eur J Immunogenet. 2004 Feb;31(1):11-4.

    Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behçet's disease.

    Source

    Gastroenterology Unit, University of Oxford, Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK.

    Erratum in

    • Eur J Immunogenet. 2005 Jun;32(3):219. Verity, D [added].

    Abstract

    Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Delta32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behçet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51.

    PMID:
    15009175
    [PubMed - indexed for MEDLINE]

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