J Gene Med. 2004 Feb;6 Suppl 1:S172-83.

Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins.

Source

Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, USA. horwitz@aecom.yu.edu

Abstract

This manuscript will contain a brief review of adenovirus (Ad) biology including its structure and the spectrum of clinical diseases that it causes. Newer findings about the interactions of Ad early region 3 (E3) proteins with host proteins and signal transduction processes, which control the inflammatory response, will be described. Some of these processes affect the strategies for using Ads as vectors for gene therapy. There are many excellent reviews of some of these aspects 1. The history of the discoveries that led to the use of Ads as vectors as well as key experiments that resulted in improvements to various aspects of these systems have also been reviewed recently 2. The use of Ad E3 immunoregulatory genes to facilitate allogeneic transplantation and prevent autoimmune diabetes will be described.

PMID:: 14978760; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review Mechanisms of E3 modulation of immune and inflammatory responses. [Curr Top Microbiol Immunol. 2004]
Review Mechanisms of E3 modulation of immune and inflammatory responses.
Fessler SP, Delgado-Lopez F, Horwitz MS. Curr Top Microbiol Immunol. 2004; 273:113-35.
Inhibition of chemokine expression by adenovirus early region three (E3) genes. [J Virol. 2002]
Inhibition of chemokine expression by adenovirus early region three (E3) genes.
Lesokhin AM, Delgado-Lopez F, Horwitz MS. J Virol. 2002 Aug; 76(16):8236-43.
Review Subversion of host defense mechanisms by adenoviruses. [Curr Top Microbiol Immunol. 2002]
Review Subversion of host defense mechanisms by adenoviruses.
Burgert HG, Ruzsics Z, Obermeier S, Hilgendorf A, Windheim M, Elsing A. Curr Top Microbiol Immunol. 2002; 269:273-318.
Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes. [Proc Natl Acad Sci U S A. 1997]
Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes.
von Herrath MG, Efrat S, Oldstone MB, Horwitz MS. Proc Natl Acad Sci U S A. 1997 Sep 2; 94(18):9808-13.
Review Functions and mechanisms of action of the adenovirus E3 proteins. [Int Rev Immunol. 2004]
Review Functions and mechanisms of action of the adenovirus E3 proteins.
Lichtenstein DL, Toth K, Doronin K, Tollefson AE, Wold WS. Int Rev Immunol. 2004 Jan-Apr; 23(1-2):75-111.

See reviews... See all...

Cited by 21 PubMed Central articles

Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis. [PLoS One. 2011]
Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis.
Dorer DE, Holtrup F, Fellenberg K, Kaufmann JK, Engelhardt S, Hoheisel JD, Nettelbeck DM. PLoS One. 2011; 6(11):e27934. Epub 2011 Nov 30.
Open reading frame E3-10.9K of subspecies B1 human adenoviruses encodes a family of late orthologous proteins that vary in their predicted structural features and subcellular localization. [J Virol. 2010]
Open reading frame E3-10.9K of subspecies B1 human adenoviruses encodes a family of late orthologous proteins that vary in their predicted structural features and subcellular localization.
Frietze KM, Campos SK, Kajon AE. J Virol. 2010 Nov; 84(21):11310-22. Epub 2010 Aug 25.
Construction and immunogenicity of replication-competent adenovirus 5 host range mutant recombinants expressing HIV-1 gp160 of SF162 and TV1 strains. [Vaccine. 2010]
Construction and immunogenicity of replication-competent adenovirus 5 host range mutant recombinants expressing HIV-1 gp160 of SF162 and TV1 strains.
Hidajat R, Kuate S, Venzon D, Kalyanaraman V, Kalisz I, Treece J, Lian Y, Barnett SW, Robert-Guroff M. Vaccine. 2010 May 21; 28(23):3963-71. Epub 2010 Apr 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Function of adenovirus E3 proteins and their interactions with immunoregulatory ...
Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins.
J Gene Med. 2004 Feb ;6 Suppl 1:S172-83.

PubMed
Storytelling as a method for teaching values and attitudes.
Storytelling as a method for teaching values and attitudes.
Acad Med. 1992 Aug ;67(8):500-4.

PubMed
Myofibers express IL-6 after eccentric exercise.
Myofibers express IL-6 after eccentric exercise.
Am J Sports Med. 2004 Mar ;32(2):503-8.

PubMed
Low-affinity Ca(2+)-binding sites versus Zn(2+)-binding sites in histidine-rich ...
Low-affinity Ca(2+)-binding sites versus Zn(2+)-binding sites in histidine-rich Ca(2+)-binding protein of skeletal muscle sarcoplasmic reticulum.
Biochem Biophys Res Commun. 1992 Jul 31 ;186(2):659-67.

PubMed
MAPK cascade signalling and synaptic plasticity.
MAPK cascade signalling and synaptic plasticity.
Nat Rev Neurosci. 2004 Mar ;5(3):173-83.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 21 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information