Arch Intern Med. 1992 Aug;152(8):1625-9.

Gaps in the anion gap.

Salem MM, Mujais SK.

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Department of Medicine, Northwestern University Medical School, Chicago, Ill.

Abstract

OBJECTIVE:

To review limitations of the use of serum anion gap in clinical practice.

DATA SOURCES:

Original reports and reviews.

STUDY SELECTION:

Sources containing the most recent pertinent information.

DATA SYNTHESIS:

Theoretical and practical limitations beset the use of serum anion gap. Awareness of these limitations reduces but does not eliminate wrong diagnoses based on the anion gaps.

CONCLUSIONS:

Serum anion gap has a limited value in the differential diagnosis of acid-base disorders and can be misleading.

PMID:: 1497396; [PubMed - indexed for MEDLINE]

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