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    Cancer Res. 2004 Feb 1;64(3):969-76.

    RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer.

    Ren C, Li L, Yang G, Timme TL, Goltsov A, Ren C, Ji X, Addai J, Luo H, Ittmann MM, Thompson TC.

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    Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA.

    Abstract

    We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. In this report, we document that the human RTVP-1 gene is also regulated by p53 and induces apoptosis in human prostate cancer cell lines. We show that the expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. We further document epigenetic changes consistent with RTVP-1 being a tumor suppressor in human prostate cancer.

    PMID:
    14871827
    [PubMed - indexed for MEDLINE]
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