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Genome Biol. 2004;5(2):R11. Epub 2004 Jan 16.

Predicting specificity in bZIP coiled-coil protein interactions.

Fong JH, Keating AE, Singh M.

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Computer Science Department and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Olden Street, Princeton, NJ 08544, USA.

Abstract

We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach for predicting coiled-coil interactions more generally.

PMID:: 14759261; [PubMed - indexed for MEDLINE]
PMCID: PMC395749

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