Kidney Int. 1992 Dec;42(6):1457-61.

Vascular permeability factor mRNA and protein expression in human kidney.

Brown LF, Berse B, Tognazzi K, Manseau EJ, Van de Water L, Senger DR, Dvorak HF, Rosen S.

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Department of Pathology, Beth Israel Hospital, Boston, Massachusetts.

Abstract

Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a potent microvascular permeability-enhancing mediator as well as a selective mitogen for vascular endothelium. In this study, in situ hybridization and immunohistochemistry co-localized VPF mRNA and protein to glomerular visceral epithelial cells in human kidneys. Northern analysis confirmed the presence of VPF mRNA of expected size. The finding of VPF in renal glomerular epithelium identifies a potent mediator of permeability and endothelial proliferation whose role in renal physiology and pathology requires investigation.

PMID:: 1474780; [PubMed - indexed for MEDLINE]

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