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    FEBS Lett. 2004 Jan 16;557(1-3):243-7.

    Creatine increases IGF-I and myogenic regulatory factor mRNA in C(2)C(12) cells.

    Louis M, Van Beneden R, Dehoux M, Thissen JP, Francaux M.

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    Département d'Education Physique et de Réadaptation, Université catholique de Louvain, Place Pierre de Coubertin 1, B-1348 Louvain-la-Neuve, Belgium. magali.louis@edph.ucl.ac.be

    Abstract

    Addition of creatine to the differentiation medium of C(2)C(12) cells leads to hypertrophy of the myotubes. To investigate the implication of insulin-like growth factor I (IGF-I) and myogenic regulatory factors (MRFs) in this hypertrophy, their mRNA levels were assessed during the first 72 h of differentiation. Creatine significantly increased the IGF-I mRNA level over the whole investigated period of time, whereas the MRF mRNA levels were only augmented at precise moments, suggesting a general activation mechanism for IGF-I and a specifically regulated mechanism for MRF transcription. Our results suggest therefore that creatine-induced hypertrophy of C(2)C(12) cells is at least partially mediated by overexpression of IGF-I and MRFs.

    PMID:
    14741375
    [PubMed - indexed for MEDLINE]

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