Nutr J. 2004 Jan 16;3:2.

Iron supplements: the quick fix with long-term consequences.

Source

School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, UK. Af19@bton.ac.uk

Abstract

Co-supplementation of ferrous salts with vitamin C exacerbates oxidative stress in the gastrointestinal tract leading to ulceration in healthy individuals, exacerbation of chronic gastrointestinal inflammatory diseases and can lead to cancer. Reactive oxygen and nitrogen species (RONS) have been ascribed an important role in oxidative stress. Redox-active metal ions such as Fe(II) and Cu(I) further activate RONS and thus perpetuate their damaging effects. Ascorbic acid can exert a pro-oxidant effect by its interaction with metal ions via a number of established RONS generating systems which are reviewed here. Further studies are required to examine the detrimental effects of nutraceuticals especially in chronic inflammatory conditions which co-present with anaemia.

PMID:: 14728718; [PubMed]
PMCID: PMC340385

Free PMC Article

Images from this publication.See all images (2) Free text

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Vitamin C contributes to inflammation via radical generating mechanisms: a cautionary note. [Med Hypotheses. 2003]
Vitamin C contributes to inflammation via radical generating mechanisms: a cautionary note.
Fisher AE, Naughton DP. Med Hypotheses. 2003 Nov-Dec; 61(5-6):657-60.
Therapeutic chelators for the twenty first century: new treatments for iron and copper mediated inflammatory and neurological disorders. [Curr Drug Deliv. 2005]
Therapeutic chelators for the twenty first century: new treatments for iron and copper mediated inflammatory and neurological disorders.
Fisher AE, Naughton DP. Curr Drug Deliv. 2005 Jul; 2(3):261-8.
Review Metals, toxicity and oxidative stress. [Curr Med Chem. 2005]
Review Metals, toxicity and oxidative stress.
Valko M, Morris H, Cronin MT. Curr Med Chem. 2005; 12(10):1161-208.
Superoxide and hydrogen peroxide suppression by metal ions and their EDTA complexes. [Biochem Biophys Res Commun. 2004]
Superoxide and hydrogen peroxide suppression by metal ions and their EDTA complexes.
Fisher AE, Maxwell SC, Naughton DP. Biochem Biophys Res Commun. 2004 Mar 26; 316(1):48-51.
Review Novel peptoids for the detection and suppression of reactive oxygen and nitrogen species. [Biochem Soc Trans. 2003]
Review Novel peptoids for the detection and suppression of reactive oxygen and nitrogen species.
Fisher AE, Naughton DP. Biochem Soc Trans. 2003 Dec; 31(Pt 6):1302-4.

See reviews... See all...

Cited by 4 PubMed Central articles

Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements. [Nutr J. 2010]
Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements.
Rabovsky AB, Komarov AM, Ivie JS, Buettner GR. Nutr J. 2010 Nov 23; 9:61. Epub 2010 Nov 23.
The age-gender-status profile of high performing athletes in the UK taking nutritional supplements: lessons for the future. [J Int Soc Sports Nutr. 2008]
The age-gender-status profile of high performing athletes in the UK taking nutritional supplements: lessons for the future.
Petroczi A, Naughton DP. J Int Soc Sports Nutr. 2008 Jan 10; 5:2. Epub 2008 Jan 10.
Performance enhancement with supplements: incongruence between rationale and practice. [J Int Soc Sports Nutr. 2007]
Performance enhancement with supplements: incongruence between rationale and practice.
Petróczi A, Naughton DP, Mazanov J, Holloway A, Bingham J. J Int Soc Sports Nutr. 2007 Nov 12; 4:19. Epub 2007 Nov 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Iron supplements: the quick fix with long-term consequences.
Iron supplements: the quick fix with long-term consequences.
Nutr J. 2004 Jan 16 ;3:2.

PubMed
Should the nonaromatizable androgen dihydrotestosterone be considered as an alte...
Should the nonaromatizable androgen dihydrotestosterone be considered as an alternative to testosterone in the treatment of the andropause?
J Clin Endocrinol Metab. 2002 Apr ;87(4):1462-6.

PubMed
Effects of a water-soluble cinnamon extract on body composition and features of ...
Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women.
J Int Soc Sports Nutr. 2006 Dec 28 ;3:45-53.

PubMed
Magnesium, zinc, and chromium nutrition and athletic performance.
Magnesium, zinc, and chromium nutrition and athletic performance.
Can J Appl Physiol. 2001 ;26 Suppl:S13-22.

PubMed
Zinc status in athletes: relation to diet and exercise.
Zinc status in athletes: relation to diet and exercise.
Sports Med. 2001 ;31(8):577-82.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Iron supplements: the quick fix with long-term consequences.

Source

Abstract

LinkOut - more resources

Full Text Sources

Libraries

Supplemental Content

Related citations

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information