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Genome Biol. 2003;5(1):R6. Epub 2003 Dec 15.

Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network.

Brun C, Chevenet F, Martin D, Wojcik J, Guénoche A, Jacq B.

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Laboratoire de Génétique et Physiologie du Développement, CNRS UMR6545, Parc Scientifique et Technologique de Luminy, Case 907, 13288 Marseille Cedex 9, France.

Abstract

We here describe PRODISTIN, a new computational method allowing the functional clustering of proteins on the basis of protein-protein interaction data. This method, assessed biologically and statistically, enabled us to classify 11% of the Saccharomyces cerevisiae proteome into several groups, the majority of which contained proteins involved in the same biological process(es), and to predict a cellular function for many otherwise uncharacterized proteins.

PMID:: 14709178; [PubMed - indexed for MEDLINE]
PMCID: PMC395738

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