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    Am J Psychiatry. 1978 Mar;135(3):352-4.

    Sodium valproate in Huntington's disease.

    Symington GR, Leonard DP, Shannon PJ, Vajda FJ.

    Abstract

    The authors assessed the effect of sodium valproate, which is thought to elevate brain gamma-aminobutyric acid (GABA) levels, in the treatment of Huntington's disease by an objective ultrasound method in three patients with Huntington's disease. Despite plasma levels ranging from 47.0 to 140.8 microgram/ml (mean, 104.7), sodium valproate had no beneficial effect on involuntary movements. The authors stress the importance of activation to achieve a standard level of arousal in the assessment of involuntary movements.

    PMID:
    147033
    [PubMed - indexed for MEDLINE]

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