Int J Biol Macromol. 2003 Nov;33(1-3):19-22.

Retention of enzyme gene duplicates by subfunctionalization.

Source

Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden. chefnb@sbc.su.se

Abstract

Duplication-degeneration-complementation (DDC) describes a process by which evolving duplicates of a pleiotropic ancestral gene divide up the multiple functions of the ancestor between them (i.e. subfunctionalize), and this ultimately frustrates the rate of pseudogene formation. Focusing explicitly on enzyme-like pleiotropic function, we model DDC driven by sequence divergence between duplicates. The model incorporates an idealized sequence-function mapping in which enzyme-substrate binding affinity is related to hydrophobic versus polar (HP) amino-acid composition of tertiary structure about the binding pocket. In this sense, a transparent coupling between physical-chemical function of an enzyme and sequence evolution is presented.

PMID:: 14599579; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Enzymes

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