Int J Immunopharmacol. 1992 Oct;14(7):1139-43.

Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway.

Source

Pharmacology Division, Regional Research Laboratory, Jammu Tawi, India.

Abstract

Boswellic acids (BA), an anti-inflammatory and anti-arthritic principle/s of Boswellia serrata, were found to possess anticomplementary activity. It inhibits the in vitro immunohaemolysis of antibody-coated sheep erythrocytes by pooled guinea-pig serum. The reduced immunohaemolysis was found to be due to inhibition of C3-convertase of the classical complement pathway. The threshold concentration for inhibiting C3-convertase was found to be 100 micrograms. However, higher concentrations of BA showed constant inhibitory effects on immunohaemolysis. BA also exhibited weak inhibitory effects on individual components of the complement system. In vivo administration of BA also showed the inhibitory effect on guinea-pig serum.

PMID:: 1452399; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

In Vitro

MeSH Terms

Substances

LinkOut - more resources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Anti-complement activity of oleanolic acid: an inhibitor of C3-convertase of the classical complement pathway. [J Pharm Pharmacol. 1994]
Anti-complement activity of oleanolic acid: an inhibitor of C3-convertase of the classical complement pathway.
Kapil A, Sharma S. J Pharm Pharmacol. 1994 Nov; 46(11):922-3.
Rosmarinic acid: a new inhibitor of complement C3-convertase with anti-inflammatory activity. [Int J Immunopharmacol. 1988]
Rosmarinic acid: a new inhibitor of complement C3-convertase with anti-inflammatory activity.
Englberger W, Hadding U, Etschenberg E, Graf E, Leyck S, Winkelmann J, Parnham MJ. Int J Immunopharmacol. 1988; 10(6):729-37.
The inhibitory effect of factor J on the alternative complement pathway. [J Biol Chem. 1994]
The inhibitory effect of factor J on the alternative complement pathway.
González-Rubio C, Jiménez-Clavero MA, Fontán G, López-Trascasa M. J Biol Chem. 1994 Oct 21; 269(42):26017-24.
The inhibitory effect of rosmarinic acid on complement involves the C5 convertase. [Int J Immunopharmacol. 1991]
The inhibitory effect of rosmarinic acid on complement involves the C5 convertase.
Peake PW, Pussell BA, Martyn P, Timmermans V, Charlesworth JA. Int J Immunopharmacol. 1991; 13(7):853-7.
Review Modulation of the immune system by Boswellia serrata extracts and boswellic acids. [Phytomedicine. 2010]
Review Modulation of the immune system by Boswellia serrata extracts and boswellic acids.
Ammon HP. Phytomedicine. 2010 Sep; 17(11):862-7. Epub 2010 Aug 8.

See reviews... See all...

Cited by 1 PubMed Central article

Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats. [Chin Med. 2011]
Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats.
Ali EN, Mansour SZ. Chin Med. 2011 Sep 30; 6:36. Epub 2011 Sep 30.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of ...
Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway.
Int J Immunopharmacol. 1992 Oct ;14(7):1139-43.

PubMed
STUDIES ON SAPONINS AND SAPOGENINS OF GINSENG. THE STRUCTURE OF PANAXATRIOL.
STUDIES ON SAPONINS AND SAPOGENINS OF GINSENG. THE STRUCTURE OF PANAXATRIOL.
Tetrahedron Lett. 1965 Jan ;42:207-13.

PubMed
Effect of 17 beta-oestradiol on lymphocyte subpopulations, delayed cutaneous hyp...
Effect of 17 beta-oestradiol on lymphocyte subpopulations, delayed cutaneous hypersensitivity responses and mixed lymphocyte reactions in post-menopausal women.
Maturitas. 1992 Mar ;14(3):201-10.

PubMed
Radiological assessment of osteo-arthrosis.
Radiological assessment of osteo-arthrosis.
Ann Rheum Dis. 1957 Dec ;16(4):494-502.

PubMed
Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance g...
Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite.
FEBS Lett. 1992 Apr 27 ;301(3):307-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: