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Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77550.
Stimulation in the ventrobasal complex of the thalamus relieves neuropathic pain and inhibits spinal cord transmission of nociceptive information. Electrical stimulation of the ventral posterior nucleus of the thalamus elicited increases in extracellular serotonin concentration in the spinal cords of anesthetized monkeys. These results suggest that thalamic stimulation activates the raphe-spinal tract and thus implicates serotonin as a mediator of thalamic stimulation induced analgesia.
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