Mutat Res. 1992 Feb;265(2):165-71.

Thioguanine-resistant mutant frequency in T-lymphocytes from a healthy human population.

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BIBRA Toxicology International, Carshalton, Surrey, Great Britain.

Abstract

Resistance to 6-thioguanine in T-lymphocytes was used to study in vivo somatic mutations in normal healthy adults. Donor age had a significant effect on mutant frequency at the hprt locus, showing an increase of 0.09/10(6) cells per year of age. No significant increase was associated with sex of donor, smoking habits, alcohol or coffee/tea intake, or X-ray exposure. The lower mutant frequency seen with contraceptive pill usage was probably due to the age difference between the groups of users and non-users.

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Mutat Res. 1992 Feb ;265(2):165-71.

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