J Gen Virol. 2003 Oct;84(Pt 10):2723-7.

A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria.

Meertens L, Shanmugam V, Gessain A, Beer BE, Tooze Z, Heneine W, Switzer WM.

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Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département d'Ecosystème et Epidémiologie des Maladies Infectieuses, Batiment Lwoff, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France.

Abstract

We present here a novel, distinct simian T-cell lymphotropic virus (STLV) found in a red-capped mangabey (Cercocebus torquatus) (CTO-NG409), wild-caught in Nigeria, that showed an HTLV-2-like Western blot (WB) seroreactivity. The complete genome (8920 bp) of CTO-NG409 STLV was related to but different from STLV-3/PHA-PH969 (13.5 %) and STLV-3/PPA-F3 (7.6 %), and STLV-3/CTO604 (11.3 %), found in Eritrean and Senegalese baboons, and red-capped mangabeys from Cameroon, respectively. Phylogenetic analysis of a conserved tax (180 bp) sequence and the env gene (1482 bp) confirmed the relatedness of STLV-3/CTO-NG409 to the STLV-3 subgroup. Molecular clock analysis of env estimated that STLV-3/CTO-NG409 diverged from East and West/Central African STLV-3s about 140,900+/-12,400 years ago, suggesting an ancient African origin of STLV-3. Since phylogenetic evidence suggests multiple interspecies transmissions of STLV-1 to humans, and given the antiquity and wide distribution of STLV-3 in Africa, a search for STLV-3 in human African populations with HTLV-2-like WB patterns is warranted.

PMID:: 13679606; [PubMed - indexed for MEDLINE]

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MeSH Terms, Substances, Secondary Source ID

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Antibodies, Viral

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GENBANK/AY222339

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