Trends Biochem Sci. 2003 Sep;28(9):488-94.

VEGF-receptor signal transduction.

Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.

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Department of Genetics and Pathology, Dag Hammarskjöldsväg 20, 751 85 Uppsala, Sweden.

Abstract

The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult. This has facilitated a rapid transition to their use in clinical applications, for example, administration of VEGF ligands to enhance vascularization of ischaemic tissues and, conversely, inhibitors of VEGF-receptor function in anti-angiogenic therapy. More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis.

PMID:: 13678960; [PubMed - indexed for MEDLINE]

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