Biochem Biophys Res Commun. 1992 Sep 16;187(2):744-50.

de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite.

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Department of Biochemistry, Indian Institute of Science, Bangalore.

Abstract

The human malarial parasite, Plasmodium falciparum, has been found to synthesize heme de novo, despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite delta-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability.

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de novo biosynthesis of heme offers a new chemotherapeutic target in the human m...
de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite.
Biochem Biophys Res Commun. 1992 Sep 16 ;187(2):744-50.

PubMed
Giant-cell granuloma of the respiratory tract (Wegener's granulomatosis).
Giant-cell granuloma of the respiratory tract (Wegener's granulomatosis).
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Anal Biochem. 1992 May 1 ;202(2):348-55.

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de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite.

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