J Steroid Biochem Mol Biol. 1992 Sep;43(1-3):21-5.

Hormonal regulation of c-erbB-2 oncogene expression in breast cancer cells.

De Bortoli M, Dati C, Antoniotti S, Maggiora P, Sapei ML.

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Department of Animal Biology, University of Turin, Torino, Italy.

Abstract

Expression of the c-erbB-2 (neu, HER-2) oncogene is found to be subjected to hormonal and developmental regulation in normal as well as neoplastic mammary cells. We have previously reported that estrogens inhibit c-erbB-2 expression at both the mRNA and protein level in estrogen receptor (ER)-positive, but not in ER-negative, breast cancer cell lines. Reversion of c-erbB-2 inhibition is seen with tamoxifen. The effect on c-erbB-2 expression of several other hormones and factors, which influence mammary cell growth and differentiation, has been studied. Our observations indicate that, in normal and neoplastic mammary cells, c-erbB-2 expression is inversely related to cell proliferation. While estrogens, anti-estrogens and cAMP clearly regulate c-erbB-2 mRNA levels, epidermal growth factor dramatically decreases the c-erbB-2 protein without affecting the level of c-erbB-2 mRNA. Therefore, different signals converging in terms of cell proliferation regulate c-erbB-2 expression by different molecular mechanisms.

PMID:: 1356014; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

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