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    FEBS Lett. 1992 Jul 27;307(1):102-7.

    NO., CO and .OH. Endogenous soluble guanylyl cyclase-activating factors.

    Source

    Northwestern University Medical School, Department of Pharmacology, Chicago, IL 60611.

    Abstract

    Several low molecular weight compounds are capable of activating soluble guanylyl cyclase. Recent evidence suggests that some of these are formed under physiological conditions: the nitric oxide radical, carbon monoxide and the hydroxyl radical. Thus, multiple signal transduction pathways appear to exist that form a family of guanylyl cyclase activating factors and thereby regulate the intracellular cyclic guanosine 3',5'-monophosphate level.

    PMID:
    1353461
    [PubMed - indexed for MEDLINE]

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