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    Cell. 1992 Dec 11;71(6):1003-14.

    TGF beta signals through a heteromeric protein kinase receptor complex.

    Wrana JL, Attisano L, Cárcamo J, Zentella A, Doody J, Laiho M, Wang XF, Massagué J.

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    Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

    Abstract

    Transforming growth factor beta (TGF beta) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.

    PMID:
    1333888
    [PubMed - indexed for MEDLINE]

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