Nat Rev Cancer. 2003 Oct;3(10):721-32.

Targeting HIF-1 for cancer therapy.

Source

McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914, USA. gsemenza@jhmi.edu

Abstract

Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion. Intratumoral hypoxia and genetic alterations can lead to HIF-1alpha overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics.

PMID:: 13130303; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review HIF-1 and tumor progression: pathophysiology and therapeutics. [Trends Mol Med. 2002]
Review HIF-1 and tumor progression: pathophysiology and therapeutics.
Semenza GL. Trends Mol Med. 2002; 8(4 Suppl):S62-7.
Review New anticancer strategies targeting HIF-1. [Biochem Pharmacol. 2004]
Review New anticancer strategies targeting HIF-1.
Yeo EJ, Chun YS, Park JW. Biochem Pharmacol. 2004 Sep 15; 68(6):1061-9.
Review Hypoxia-inducible factor 1 (HIF-1) in cancer. [Eur J Surg Oncol. 2004]
Review Hypoxia-inducible factor 1 (HIF-1) in cancer.
Quintero M, Mackenzie N, Brennan PA. Eur J Surg Oncol. 2004 Jun; 30(5):465-8.
Review [Hypoxia-inducible factor 1: regulation, involvement in carcinogenesis and target for anticancer therapy]. [Bull Cancer. 2005]
Review [Hypoxia-inducible factor 1: regulation, involvement in carcinogenesis and target for anticancer therapy].
Clottes E. Bull Cancer. 2005 Feb; 92(2):119-27.
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. [Cancer Res. 2005]
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, et al. Cancer Res. 2005 Jan 15; 65(2):605-12.

See reviews... See all...

Cited by over 100 PubMed Central articles

Molecular mechanisms of preeclampsia. [J Pregnancy. 2012]
Molecular mechanisms of preeclampsia.
Vitoratos N, Hassiakos D, Iavazzo C. J Pregnancy. 2012; 2012:298343. Epub 2012 Feb 23.
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. [PLoS One. 2012]
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
Sonveaux P, Copetti T, De Saedeleer CJ, Végran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frérart F, et al. PLoS One. 2012; 7(3):e33418. Epub 2012 Mar 13.
Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy. [Clin Epigenetics. 2011]
Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy.
Thirlwell C, Schulz L, Dibra H, Beck S. Clin Epigenetics. 2011 Dec 5; 3:9. Epub 2011 Dec 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Targeting HIF-1 for cancer therapy.
Targeting HIF-1 for cancer therapy.
Nat Rev Cancer. 2003 Oct ;3(10):721-32.

PubMed
Depletion of intracellular calcium stores activates a calcium current in mast ce...
Depletion of intracellular calcium stores activates a calcium current in mast cells.
Nature. 1992 Jan 23 ;355(6358):353-6.

PubMed
Transcriptional regulation by calcium, calcineurin, and NFAT.
Transcriptional regulation by calcium, calcineurin, and NFAT.
Genes Dev. 2003 Sep 15 ;17(18):2205-32.

PubMed
A functional connection between the pores of distantly related ion channels as r...
A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels.
Science. 1992 Nov 13 ;258(5085):1152-5.

PubMed
From autopoiesis to neurophenomenology: Francisco Varela's exploration of the bi...
From autopoiesis to neurophenomenology: Francisco Varela's exploration of the biophysics of being.
Biol Res. 2003 ;36(1):27-65.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Targeting HIF-1 for cancer therapy.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information