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    Science. 1992 Feb 21;255(5047):989-91.

    The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.

    de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT.

    Source

    Department of Medicine, University of California, San Francisco 94143.

    Abstract

    The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.

    PMID:
    1312256
    [PubMed - indexed for MEDLINE]

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