J Biol. 2003;2(3):18. Epub 2003 Sep 11.

Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors.

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Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. neufeld@med.umn.edu

Abstract

The insulin signaling pathway regulates organismal growth in response to nutrient conditions by controlling a range of metabolic and biosynthetic processes. Recent studies in Drosophila have shown how transcriptional responses to reduced insulin and nutrient levels can act to inhibit growth.

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PMCID: PMC333402

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Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors.

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