J Theor Biol. 1992 Nov 21;159(2):199-214.

On the origin of the transfer RNA molecule.

Source

International Institute of Genetics and Biophysics, CNR, Naples, Italy.

Abstract

Data and arguments are given in favour of the hypothesis that the primitive tRNA molecule may have originated from a direct duplication event involving one of the two halves of the tRNA molecule. It seems that a molecule capable of assuming a hairpin structure was involved as a precursor in this duplication. The two halves of the present tRNAs could, therefore, be considered as paralogous.

PMID:: 1294846; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

RNA, Transfer

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Was it an ancient gene codifying for a hairpin RNA that, by means of direct duplication, gave rise to the primitive tRNA molecule? [J Theor Biol. 1995]
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Cited by 9 PubMed Central articles

On origin of genetic code and tRNA before translation. [Biol Direct. 2011]
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RNA relics and origin of life. [Int J Mol Sci. 2009]
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