Nucleic Acids Symp Ser. 1992;(27):181-2.

Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

Kasai H, Yamaizumi Z, Yamamoto F, Bessho T, Nishimura S, Berger M, Cadet J.

Source

Biology Division, National Cancer Center Research Institute, Tokyo, Japan.

Abstract

Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.

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Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA ...
Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.
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