Clin Infect Dis. 2003 Aug 1;37(3):450-1. Epub 2003 Jul 18.

Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa.

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Center for Geographic Medicine and Department of Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Abstract

We report a case of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser).

PMID:: 12884171; [PubMed - indexed for MEDLINE]

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Chemical compound information

Proguanil

MW: 253.73 g/mol

MF: C₁₁H₁₆ClN₅

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Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa.

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