Lymphology. 1992 Dec;25(4):166-71.

Immune proteins in peripheral tissue fluid-lymph in patients with filarial lymphedema of the lower limbs.

Olszewski WL, Jamal S, Lukomska B, Manokaran G, Grzelak I.

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Department of Surgical Research & Transplantology, Polish Academy of Sciences, Warsaw.

Abstract

Immune proteins and cytokine concentrations and activity were measured in skin tissue fluid-lymph and blood serum of patients with lower leg filarial lymphedema. High levels of lymph gamma-globulins, alpha-1-acid glycoprotein and IgG lymph/serum ratio were found. Lymph from filarial patients had an elevated lymph stimulatory effect on blood mononuclear cell culture with phytohemagglutinin. There was also a high concentration and activity of IL-1 beta but gamma-interferon was not detected. The deranged pattern of immune proteins and high activity of IL-1 suggest persistence of an ongoing local inflammatory process despite the absence of overt dermatitis. The high tissue-lymph IL-1 concentration and activity may signify a cytokine network promoting keratinocyte and fibroblast proliferation commonly seen on skin histology in patients with filariasis.

PMID:: 1284085; [PubMed - indexed for MEDLINE]

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