J Clin Invest. 2003 Jun;111(12):1819-21.

Tolerance: of mice and men.

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Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA. sachs@helix.mgh.harvard.edu

Abstract

Little is known about the effect of an individual's immune history on his or her response to an allogeneic tissue transplant. An important study now reveals that individuals harboring virally-induced memory T cells that are cross reactive with donor alloantigen are resistant to conventional strategies designed to induce transplant tolerance.

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J Clin Invest. 2003 Jun;111(12):1887-95.

PMID:: 12813017; [PubMed - indexed for MEDLINE]
PMCID:: PMC161433

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