Brain Res Mol Brain Res. 1992 Nov;16(1-2):143-9.

Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat.

Donaldson LF, Harmar AJ, McQueen DS, Seckl JR.

Source

University of Edinburgh, Department of Medicine, Western General Hospital, UK.

Abstract

Neuropeptides in dorsal root ganglia (DRG) have been implicated in the pathogenesis of pain and neurogenic inflammation in experimental and clinical arthritis. Recently we demonstrated increased levels of substance P (SP) and calcitonin gene-related peptide (CGRP) confined to innervating DRG in adjuvant-mediated monoarthritis. We have now investigated whether changes in peptide content are reflected in altered neuropeptide gene expression and the time course involved. Using in situ hybridization we found marked increases in expression of beta-preprotachykinin (PPT; 81 +/- 24% rise) and alpha-CGRP (44 +/- 6% rise) mRNAs in innervating (ipsilateral L5) DRG neurones only. These increases occurred at the onset of acute inflammation (8 h) and persisted until chronic arthritis developed after 14 days. There were no changes in the proportion of DRG neurones expressing PPT or CGRP mRNAs. Messenger RNA encoding vasoactive intestinal polypeptide (VIP) was not induced. These data suggest that increased synthesis of PPT and CGRP peptides in DRG may play a role in the pathogenesis both of adjuvant-mediated acute inflammation and chronic arthritis.

PMID:: 1281253; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Adjuvant-induced joint inflammation causes very rapid transcription of beta-preprotachykinin and alpha-CGRP genes in innervating sensory ganglia. [J Neurochem. 2001]
Adjuvant-induced joint inflammation causes very rapid transcription of beta-preprotachykinin and alpha-CGRP genes in innervating sensory ganglia.
Bulling DG, Kelly D, Bond S, McQueen DS, Seckl JR. J Neurochem. 2001 Apr; 77(2):372-82.
Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation. [Neuroscience. 1995]
Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation.
Galeazza MT, Garry MG, Yost HJ, Strait KA, Hargreaves KM, Seybold VS. Neuroscience. 1995 May; 66(2):443-58.
Neuropeptide gene expression and capsaicin-sensitive primary afferents: maintenance and spread of adjuvant arthritis in the rat. [J Physiol. 1995]
Neuropeptide gene expression and capsaicin-sensitive primary afferents: maintenance and spread of adjuvant arthritis in the rat.
Donaldson LF, McQueen DS, Seckl JR. J Physiol. 1995 Jul 15; 486 ( Pt 2):473-82.
Local anaesthesia prevents acute inflammatory changes in neuropeptide messenger RNA expression in rat dorsal root ganglia neurons. [Neurosci Lett. 1994]
Local anaesthesia prevents acute inflammatory changes in neuropeptide messenger RNA expression in rat dorsal root ganglia neurons.
Donaldson LF, McQueen DS, Seckl JR. Neurosci Lett. 1994 Jul 4; 175(1-2):111-3.
Review Tachykinin and calcitonin gene-related peptide immunoreactivities and mRNAs in the mammalian enteric nervous system and sensory ganglia. [Adv Exp Med Biol. 1991]
Review Tachykinin and calcitonin gene-related peptide immunoreactivities and mRNAs in the mammalian enteric nervous system and sensory ganglia.
Sternini C. Adv Exp Med Biol. 1991; 298:39-51.

See reviews... See all...

Cited by 16 PubMed Central articles

PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium. [J Mol Neurosci. 2010]
PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium.
Girard BM, Malley SE, Braas KM, May V, Vizzard MA. J Mol Neurosci. 2010 Nov; 42(3):378-89. Epub 2010 May 7.
Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons. [Neuroscience. 2010]
Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons.
Tarsa L, Bałkowiec-Iskra E, Kratochvil FJ 3rd, Jenkins VK, McLean A, Brown AL, Smith JA, Baumgartner JC, Balkowiec A. Neuroscience. 2010 Jun 2; 167(4):1205-15. Epub 2010 Mar 9.
Nuclear factor-kappa B decoy suppresses nerve injury and improves mechanical allodynia and thermal hyperalgesia in a rat lumbar disc herniation model. [Eur Spine J. 2009]
Nuclear factor-kappa B decoy suppresses nerve injury and improves mechanical allodynia and thermal hyperalgesia in a rat lumbar disc herniation model.
Suzuki M, Inoue G, Gemba T, Watanabe T, Ito T, Koshi T, Yamauchi K, Yamashita M, Orita S, Eguchi Y, et al. Eur Spine J. 2009 Jul; 18(7):1001-7. Epub 2009 Mar 24.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Increased expression of preprotachykinin, calcitonin gene-related peptide, but n...
Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat.
Brain Res Mol Brain Res. 1992 Nov ;16(1-2):143-9.

PubMed
Activation of invariant NKT cells by alphaGalCer administration protects mice fr...
Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma.
Eur J Immunol. 2003 Jul ;33(7):1830-8.

PubMed
Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and ...
Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia.
Br J Cancer. 1992 Dec ;66(6):1159-63.

PubMed
Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the i...
Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration.
Biomaterials. 2003 Sep ;24(20):3531-41.

PubMed
Activation of collagen type II expression in osteoarthritic and rheumatoid carti...
Activation of collagen type II expression in osteoarthritic and rheumatoid cartilage.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1992 ;62(6):337-45.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 16 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information