Science. 2003 Jun 13;300(5626):1701-3.

Evolution of the protein repertoire.

Chothia C, Gough J, Vogel C, Teichmann SA.

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Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

Abstract

Most proteins have been formed by gene duplication, recombination, and divergence. Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes.

PMID:: 12805536; [PubMed - indexed for MEDLINE]

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