Science. 1992 Nov 27;258(5087):1491-4.

Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy.

Gaur A, Wiers B, Liu A, Rothbard J, Fathman CG.

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Stanford University School of Medicine, Division of Immunology and Rheumatology, CA 94305.

Abstract

Experimental autoimmune encephalomyelitis (EAE), a demyelinating disease of the central nervous system that can be induced in susceptible strains of mice by immunization with myelin basic protein (MBP) or its immunodominant T cell determinants, serves as a model of human multiple sclerosis. Tolerance to MBP in adult mice was induced by intraperitoneal injection of synthetic peptides of immunodominant determinants of MBP and prevented MBP-induced EAE. Furthermore, tolerance-inducing regimens of peptides administered to mice after the disease had begun (10 days after induction with MBP) blocked the progression and decreased the severity of EAE. Peptide-induced tolerance resulted from the induction of anergy in proliferative, antigen-specific T cells.

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