Curr Opin Chem Biol. 2003 Apr;7(2):265-72.

Enzymes with extra talents: moonlighting functions and catalytic promiscuity.

Source

Department of Molecular, Cellular, and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado at Boulder Campus, Box 216, Boulder, CO 80309-0216, USA. copley@cires.colorado.edu

Abstract

Recent studies of moonlighting functions and catalytic promiscuity provide insights into the structural and mechanistic bases of these phenomena. Moonlighting proteins that are highlighted include gephyrin, the Neurospora crassa tyrosyl tRNA synthetase, phosphoglucose isomerase, and cytochrome c. New insights into catalytic promiscuity are provided by studies of aminoglycoside kinase (3') type IIIa, tetrachlorohydroquinone dehalogenase, and aldolase antibody 38C2.

PMID:: 12714060; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Enzymes

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Review Enzyme promiscuity: a mechanistic and evolutionary perspective. [Annu Rev Biochem. 2010]
Review Enzyme promiscuity: a mechanistic and evolutionary perspective.
Khersonsky O, Tawfik DS. Annu Rev Biochem. 2010; 79:471-505.
A quantitative index of substrate promiscuity. [Biochemistry. 2008]
A quantitative index of substrate promiscuity.
Nath A, Atkins WM. Biochemistry. 2008 Jan 8; 47(1):157-66. Epub 2007 Dec 15.
Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways. [Angew Chem Int Ed Engl. 2004]
Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways.
Bornscheuer UT, Kazlauskas RJ. Angew Chem Int Ed Engl. 2004 Nov 19; 43(45):6032-40.
Review Enzyme promiscuity: evolutionary and mechanistic aspects. [Curr Opin Chem Biol. 2006]
Review Enzyme promiscuity: evolutionary and mechanistic aspects.
Khersonsky O, Roodveldt C, Tawfik DS. Curr Opin Chem Biol. 2006 Oct; 10(5):498-508. Epub 2006 Aug 30.
Review Enzyme promiscuity: mechanism and applications. [Trends Biotechnol. 2007]
Review Enzyme promiscuity: mechanism and applications.
Hult K, Berglund P. Trends Biotechnol. 2007 May; 25(5):231-8. Epub 2007 Mar 26.

See reviews... See all...

Cited by 38 PubMed Central articles

Review Microbial laboratory evolution in the era of genome-scale science. [Mol Syst Biol. 2011]
Review Microbial laboratory evolution in the era of genome-scale science.
Conrad TM, Lewis NE, Palsson BØ. Mol Syst Biol. 2011 Jul 5; 7:509. Epub 2011 Jul 5.
The coupling of pathways and processes through shared components. [BMC Syst Biol. 2011]
The coupling of pathways and processes through shared components.
Seaton DD, Krishnan J. BMC Syst Biol. 2011 Jun 29; 5:103. Epub 2011 Jun 29.
The self-organizing fractal theory as a universal discovery method: the phenomenon of life. [Theor Biol Med Model. 2011]
The self-organizing fractal theory as a universal discovery method: the phenomenon of life.
Kurakin A. Theor Biol Med Model. 2011 Mar 29; 8:4. Epub 2011 Mar 29.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Enzymes with extra talents: moonlighting functions and catalytic promiscuity.
Enzymes with extra talents: moonlighting functions and catalytic promiscuity.
Curr Opin Chem Biol. 2003 Apr ;7(2):265-72.

PubMed
Shared promiscuous activities and evolutionary features in various members of th...
Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily.
Biochemistry. 2005 Sep 27 ;44(38):12728-36.

PubMed
Enzyme promiscuity: evolutionary and mechanistic aspects.
Enzyme promiscuity: evolutionary and mechanistic aspects.
Curr Opin Chem Biol. 2006 Oct ;10(5):498-508. Epub 2006 Aug 30 .

PubMed
Relative tolerance of mesostable and thermostable protein homologs to extensive ...
Relative tolerance of mesostable and thermostable protein homologs to extensive mutation.
Proteins. 2007 Feb 1 ;66(2):500-6.

PubMed
Exploration, normalization, and summaries of high density oligonucleotide array ...
Exploration, normalization, and summaries of high density oligonucleotide array probe level data.
Biostatistics. 2003 Apr ;4(2):249-64.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: