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    Science. 2003 Mar 14;299(5613):1713-6. Epub 2003 Feb 13.

    Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton.

    Source

    Department of Immunology, Imperial College London, St. Mary's Campus, Norfolk Place, London W2 1PG, UK.

    Abstract

    Cell contact is required for efficient transmission of human T cell leukemia virus- type 1 (HTLV-I) between cells and between individuals, because naturally infected lymphocytes produce virtually no cell-free infectious HTLV-I particles. However, the mechanism of cell-to-cell spread of HTLV-I is not understood. We show here that cell contact rapidly induces polarization of the cytoskeleton of the infected cell to the cell-cell junction. HTLV-I core (Gag protein) complexes and the HTLV-I genome accumulate at the cell-cell junction and are then transferred to the uninfected cell. Other lymphotropic viruses, such as HIV-1, may similarly subvert normal T cell physiology to allow efficient propagation between cells.

    PMID:
    12589003
    [PubMed - indexed for MEDLINE]

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