Breast Cancer Res. 2002;4(6):209-12. Epub 2002 Oct 3.

Prolactin signaling and Stat5: going their own separate ways?

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Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland. Cathrin.Brisken@isrec.unil.ch

Abstract

Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR-/- and Stat5ab-/- mouse mammary epithelial transplants during pregnancy. At first glance, the two mutant epithelia appear to have similar defects in the differentiation of the alveolar epithelium. However, a closer examination by Miyoshi et al. revealed defects in the epithelial architecture of the smallest ducts of Stat5ab-/- transplants not apparent in the PrlR-/- transplants, suggesting that Stat5 is more than a simple mediator of PrlR action.

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J Cell Biol. 2001 Nov 12;155(4):531-42.

PMID:: 12473164; [PubMed - indexed for MEDLINE]
PMCID: PMC137942

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