Curr Biol. 2002 Nov 19;12(22):R785-7.

Growth signaling: TSC takes its place.

Source

Growth Regulation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, WC2A 3PX, London, UK.

Abstract

The protein products of the tumor suppressor genes tuberous sclerosis complex 1 and 2 form a protein complex, TSC1-TSC2, that inhibits growth. Several new studies suggest that TSC1-TSC2 does this by inhibiting TOR and S6 kinase, and that PI 3-kinase-Akt signaling relieves this inhibition.

PMID:: 12445406; [PubMed - indexed for MEDLINE]

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